Influences of microglial lysosome dysfunction on the pathogenesis of autism spectrum disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H06829
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: Zhu Hong 金沢大学, 子どものこころの発達研究センター, 博士研究員 (90778614)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 自閉スペクトラム症 / ミクログリア

Outline of Final Research Achievements

To clarify whether lysosomal dysfunction in microglia was involved in the pathogenesis of developmental disorders, we tried to established experimental models by injecting pregnant rats with poly (I:C) (polyinosinic-polycytidylic acid). By immunohistochemical staining of embryonic brains, we find out changes in lysosome-related proteins as follows: (1) Heat shock protein 70 expression was augmented in the vascular wall. (2) Lysosomal stress-related Gpnmb (glycoprotein non-metastatic melanoma B) expression was enhanced in glial cells. These data suggest that lysosomal membranes become destabilized during the pathogenesis of developmental disorders.

Free Research Field

神経科学