2017 Fiscal Year Final Research Report
Functions of PDGFRa positive mesenchymal stem cells during the treatment of epidermolysis bullosa
Project/Area Number |
16H06951
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Osaka University |
Principal Investigator |
Shimbo Takashi 大阪大学, 医学系研究科, 特任助教(常勤) (70780609)
|
Project Period (FY) |
2016-08-26 – 2018-03-31
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Keywords | 表皮水疱症 / 間葉系幹細胞 / 網羅的遺伝子発現解析 / 単一細胞 |
Outline of Final Research Achievements |
Epidermolysis bullosa (EB) is an intractable skin genetic disorder. Previously, we found that bone marrow Pdgfra positive cells have important roles in effective tissue regeneration in EB. Here, we performed whole transcriptome analysis on bone marrow Pdgfra positive cells at a single cell level and clarified that the cells contained multiple functionally distinct cell populations. Our data will serve as a foundation for identification of the complexed tissue regeneration mechanism in EB.
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Free Research Field |
再生医学、エピジェネティクス
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