2017 Fiscal Year Final Research Report
A novel intracellular membrane traffic-dependent regulation of cancer stem cell properties
| Project/Area Number |
16H06969
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 低分子量Gタンパク質 / ARFファミリー / がん幹細胞 |
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| Outline of Final Research Achievements |
Cancer stem cells possess anti-apoptotic property. In order to develop effective drugs targeting cancer stem cells, it is important to elucidate the mechanism of anti-apoptotic property. We investigated the function of ARL11, a tumor-suppressor gene belonging to RAB/ARF GTPase family involved in intracellular membrane traffic. We found that the active form of ARL11 interacts with an actin-binding protein and induces apoptotic membrane blebbing. The inactive form of ARL11 localizes to a nuclear body involved in apoptosis. Our studies implicate that the interaction between ARL11 and the actin-binding protein and the intracellular localization of ARL11 are involved in anti-apoptotic property.
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| Free Research Field |
生化学
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