2017 Fiscal Year Final Research Report
Study of the influences on T lymphocyte subset and stem cells in BRONJ model mice
| Project/Area Number |
16H06993
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 歯学 / 顎骨壊死 / 骨代謝 / 免疫学 |
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| Outline of Final Research Achievements |
BRONJ (Bisphosphonate[BP]-related oseteonecrosis of the jaw) is intractable disease, and the etiology and treatment are not elucidated yet. Hypothesis; BRONJ is influenced by the abnormality of the immune system. I performed immunocytic analysis of femur, thymus, spleen and peripheral blood and biochemical analysis of the blood serum in normal model mouse and BRONJ model mouse. As a result, various change with the change of T lymphocyte subset such as gamma-delta T cells was observed. This study suggests the possibility that BP treatment brought about the immunosuppression in jawbone.
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| Free Research Field |
口腔外科学
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