Structural analysis mathod for lipid-derived radicals and its application

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07047
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: Kyushu University
• Principal Investigator: Matsuoka Yuta 九州大学, 薬学研究院, 助教 (20783509)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 脂質 / 質量分析

Outline of Final Research Achievements

Lipid peroxidation is the critical process for many pathological events, and it’s drastically initiated and propagated by lipid-derived radicals. Therefore, the identification of lipid radicals would contribute to elucidation of pathological mechanisms of several oxidative diseases. We herein describe the structural identification method for lipid radicals. By using this system, we successfully identified a total of 80 radical species in 4 polyunsaturated fatty acids peroxidation. This analytical system was applicable to the animal experiments, and a total of 11 radical species was structurally identified, and in our knowledge, this is the first identification system for endogenous lipid radicals.

Free Research Field

分析科学