Hepatocellular carcinoma with vessels that encapsulated tumor clusters is associated with poor prognosis and recurrence after living donor liver transplantation.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07052
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: HARADA Noboru 九州大学, 医学研究院, 准教授 (80419580)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 肝細胞癌 / 生体肝移植 / 類洞様血管構造 / 再発

Outline of Final Research Achievements

As for the results, there was more tumor aggressive grade such as low differentiation, more than tumor diameter 5cm, and the progressed stage of a disease in VETC(+, 17) group than those of VETC(-, 95) group after a living donor liver transplantation for the hepatocellular carcinoma. Five-year recurrence-free survival (RFS) was significantly better in the VETC(-) than VETC(+) group after living donor liver transplantation (52.9% vs. 85.0%, p<0.001). Then, Five-year overall survival (OS) was significantly better in the VETC(-) than VETC(+) group after living donor liver transplantation (70.1% vs. 91.3%, p<0.01).Multivariate analysis showed that VETC(+) was an independent predictor of worse RFS. In conclusion, VETC(+) structure was the poorer recurrence factor in hepatocellular patients after living donor liver transplantation.

Free Research Field

肝臓癌