Roles of a lysosomal transcription factor in osteoblast differentiation and inflammatory diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07077
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: YONESHIMA Erika 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (20779566)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 骨系細胞分化 / リソソーム転写因子

Outline of Final Research Achievements

Since osteoblasts actively synthesize bone matrix, the function of lysosome, which is a degradation system, has hardly been analyzed. Therefore, in this study, the effects of TFEB expression change on osteoblast, adipocyte and chondrocyte differentiation was analyzed. Knock down of TFEB suppressed osteoblast differentiation, whereas overexpression of TFEB promoted it. We also found that ATF4 and CHOP involved in the endoplasmic reticulum stress response undergo the negative control of the differentiation. From these findings, TFEB is considered to be a necessary factor for alleviating endoplasmic reticulum stress caused by osteoblast differentiation.

Free Research Field

歯学矯正学