2017 Fiscal Year Final Research Report
Chemical induction of brown adipocytes and regeneration therapy for diabetes
| Project/Area Number |
16H07122
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Research Collaborator |
MAZDA OSAM 京都府立医科大学, 医学研究科, 教授 (00271164)
KISHIDA TSUNAO 京都府立医科大学, 医学研究科, 准教授 (00370205)
OHGITANI ERIKO 京都府立医科大学, 医学研究科, 助教 (80300820)
YAMAMOTO KENTA 京都府立医科大学, 医学研究科, 助教 (00636160)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 糖尿病 / 移植・再生医療 |
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| Outline of Final Research Achievements |
Brown adipocytes control carbohydrate and lipid metabolism as well as body temperature by dispersing excess energy and producing heat. Diabetic patients have lost most of the function of brown adipocytes. If brown adipocytes can be induced from somatic cells of diabetic patients and transplanted back into them, such a strategy can be a novel regeneration therapy. Recently we succeeded in developing a new method to convert human dermal fibroblasts into brown adipocytes by culturing them with a small molecular compound. This method has great advantages, particularly because the cells have not been transduced with any exogenous gene, but characterization of the resultant brown adipocytes has not be achieved in detail. In this study, we optimize the inducing method, analyze the gene expression and phenotypes of the brown adipocytes, and transplant the brown adipocytes to estimate viability as well as tumorigenicity of the cells in vivo.
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| Free Research Field |
免疫学
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