Inhibition of denture plaque deposition on complete dentures by 2-methacryloyloxyethyl phosphorylcholine polymer coating

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07196
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Showa University
• Principal Investigator: Ikeya Kenji 昭和大学, 歯学部, 助教 (30783344)
• Research Collaborator: 石原 一彦 東京大学, 大学院工学系研究科マテリアル工学専攻, 教授 ; 井上 祐貴 東京大学, 大学院工学系研究科マテリアル工学専攻, 助教 ; 桑田 啓貴 昭和大学, 口腔微生物学教室, 教授 ; 森崎 弘史 昭和大学, 口腔微生物学教室, 講師 ; 山本 隆司 サンメディカル株式会社
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: PMBPAz / MPCポリマー / デンチャープラーク

Outline of Final Research Achievements

The mean ±SD percentage of plaque index was 40.7% ±19.9% on the mucosal surfaces and 28.0% ±16.8% on the polished surfaces of the control denture. The mean percentage of plaque index of PMBPAz-treated dentures significantly decreased to 17.4%% ±12.0% on the mucosal surfaces (P<.001) and 15.0% ±9.9% on the polished surfaces (P<.05). These results demonstrated the effectiveness of the treatment with the PMBPAz to inhibit the bacterial plaque deposition on complete dentures.
Denture plaque-associated infection is an issue of considerable importance for denture wearers. Treatment with PMBPAz on denture surfaces is a promising, straightforward, and safe method of preventing microbial contamination on removable dentures.

Free Research Field

バイオマテリアル