Collaborative study of pharmacoepidemiology toward personalized medicine for non-communicable diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07201
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Epidemiology and preventive medicine
• Research Institution: Showa Pharmaceutical University
• Principal Investigator: HASHIMOTO Azusa (原梓) 昭和薬科大学, 薬学部, 准教授 (20740426)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 薬剤疫学研究 / コホート研究

Outline of Final Research Achievements

In this study, we investigated whether the variation in genes involved in lipid metabolism modify the effect of the 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on serum low density lipoprotein cholesterol concentration reduction, using the information from treating physicians and pharmacies, laboratory assessments and genomic data in the Rotterdam Study in the Netherlands, a prospective population-based cohort study that aims to study the frequency and determinants of diseases in middle-aged and elderly individuals,.
We also verified the pharmacoepidemiological data from a longitudinal cohort study in Japan.

Free Research Field

疫学、薬剤疫学