2017 Fiscal Year Final Research Report
Novel method for caries prevention focusing on pathogenic bacterial biofilm formation
| Project/Area Number |
16H07386
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Arita Ken-ichi 福岡歯科大学, 口腔歯学部, 助教 (90780205)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | う蝕 / バイオフィルム / 病原微生物 / 低分子化合物 / Tfh / クラススイッチ / IgA |
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| Outline of Final Research Achievements |
The most common infections of the oral cavity, known as dental caries, are closely related to biofilm formation of cariogenic bacteria. We tested the ability of small compounds to prevent S. mutans biofilm formation. We found the small compound inhibit biofilm formation in a dose dependent manner. In addition, we have obtained some interested result about the important antigens related to pathogenic bacteria for B cell class switch response and T cell activation.
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| Free Research Field |
微生物学
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