Effect of lactic acid bacteria intake on the helth of dam and infant during pregnancy and lactation

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K00919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Seitoku University
• Principal Investigator: Komatsuzaki Noriko 聖徳大学, 人間栄養学部, 准教授 (20536312)
• Co-Investigator(Kenkyū-buntansha): 藤原 しのぶ 聖徳大学, 人間栄養学部, 准教授 (10279672) ; 佐藤 明恵 聖徳大学, 人間栄養学部, 助手 (20774003)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 乳酸菌 / プロバイオティクス / 妊娠・授乳期 / コレステロール低下作用

Outline of Final Research Achievements

We examined the effects of Lactobacillus paracasei during pregnancy and lactation on in mice fed a high-fat diet. Lb. paracasei reduces the content of liver lipids in pups of high-fat diets. It is thought that ingesting Lb. paracasei affects the formation of bacterial flora in dams.
The probiotic of Lb. paracasei was examined. Lactobacillus casei was used as a control. Lb. paracasei showed high tolerance for the gastric juice although the tolerance for bile acid was low. Cholesterol and bile acid binding abilities of Lb. paracasei was higher than L. casei. Therefore, it was suggested that Lb. paracasei may be effectively applied as probiotics Lactobaillus.

Free Research Field

食品微生物学

Academic Significance and Societal Importance of the Research Achievements

Lactobacillus paracasei NFRI 7415は、生きたまま腸に到達し、腸内細菌叢の改善に役立つと同時に、乳酸菌のコレステロール低下作用が脂質代謝や腸管免疫に影響を与えていることが示唆された。本研究の成果は、妊娠・授乳期の母親と乳児の生活習慣病予防と健康増進に寄与する新規なプロバイオティクス効果を有する食品素材となり得ると考える。