2018 Fiscal Year Final Research Report
Study on practical application of non-invasive sonodynamic cancer therapy using ultrasound sensitive substance-loaded nanoliposome
| Project/Area Number |
16K01428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安永 晋一郎 福岡大学, 医学部, 教授 (50336111)
白須 直人 福岡大学, 医学部, 講師 (70551422)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 超音波力学療法 / ドラッグデリバリーシステム / ナノメディシン |
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| Outline of Final Research Achievements |
When considering non-invasive cancer treatment, combinational sonodynamic therapy: cSDT, which combines low-intensity ultrasound and ultrasound-sensitive substances and ultrasound sensitizers, is very promising. The nanoparticles with a diameter of about 90 nm created this time were successfully accumulated in tumor tissue without accumulation in the liver. On the other hand, phase-change nanodroplets and other nanosized bubbles can not be produced as ultrasound sensitizers, and microbubbles have been used as before, but their effects as cSDT using mouse xenograft model are limited. The results suggest that cSDT requires both an ultrasound-sensitive agent and an ultrasound sensitizer with a high concentration in the tumor tissue microenvironment to enhance the anti-cancer effect.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
これまでの超音波力学療法（SDT）の効果を増強するための組合せSDT（cSDT）において，薬剤のナノ粒子への封入を試みてきた。粒子径100-200 nmでは腫瘍組織と肝臓に集積したが，粒子径約90 nmの超音波感受性物質内封ナノ粒子では，腫瘍組織に特異的に集積させることに成功した。これらの結果は，薬剤の静脈内投与によるcSDTを考える上で期待した通りの結果である。一方，超音波増感剤では，ナノサイズのものが作製できず，従来同様にマイクロバブルを用いたが，その効果は限定的であった。したがって，cSDTではナノサイズにした超音波感受性物質，増感剤の両者を腫瘍組織に集積させる必要がある。
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