Exploration of factors related to frailty and heart failure and effectiveness of cardiac rehabilitation

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K01458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kagoshima University
• Principal Investigator: Kubozono Takuro 鹿児島大学, 医歯学域医学系, 講師 (00598013)
• Co-Investigator(Kenkyū-buntansha): 宮田 昌明 鹿児島大学, 医歯学総合研究科, 客員研究員 (00347113) ; 池田 義之 鹿児島大学, 医歯学域医学系, 講師 (00573023) ; 大石 充 鹿児島大学, 医歯学域医学系, 教授 (50335345)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 心不全 / 運動耐容能 / バイオマーカー / フレイル

Outline of Final Research Achievements

In order to clarify the pathology for heart failure with frailty, we evaluated the relationship between exercise capacity and muscle strength and blood sampling data. While grip strength was associated with peak VO2, OUES was also found to be associated. Moreover, the number of lymphocytes was related to severity, which is an index of the severity of heart failure, and the significance of the number of lymphocytes in patients with heart failure was clarified. Furthermore, we examined the factors related to exercise tolerance in left heart failure and right heart failure due to pulmonary hypertension. It was revealed that the factors related to exercise tolerance were different in left heart failure and right heart failure due to pulmonary hypertension.

Free Research Field

循環器内科、心不全

Academic Significance and Societal Importance of the Research Achievements

近年、心不全患者において、骨格筋筋力をはじめとした全身の機能が低下し、健康障害を起こしやすい脆弱な状態、いわゆる虚弱 (フレイル) を合併することが問題となっているが、その病態は解明されていない。今回、慢性心不全とフレイルの指標を比較することにより、フレイルの新たな病態が明らかとされた。これにより、新たな側面とした心不全の評価方法や治療ターゲットが明らかとされた。