2018 Fiscal Year Final Research Report
Development of a practical protein-chip using designed DNA-arrays
| Project/Area Number |
16K01910
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2016-10-21 – 2019-03-31
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| Keywords | グアニン四重鎖 / 分子センサー |
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| Outline of Final Research Achievements |
This research proposal aims to create a superior protein analysis tool (protein detection device) with a viewpoint of convenience, quickness, high inspection accuracy, reproducibility, low cost etc. at a level that can be used in a clinical purpose. Here, we showed that "nucleic acid structure library" , that is rich in guanine bases, can serve as a new class of protein recognition elements.
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| Free Research Field |
生物有機化学
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| Academic Significance and Societal Importance of the Research Achievements |
今回，有機合成化学的手法と，遺伝子工学手法を融合することにより，核酸の安定な高次構造として知られるグアニン四重鎖構造を指向した多様な DNA 型素子ライブラリーを構造や配列による偏りを極力排除した形で作製することに成功した.四重鎖構造体をライブ ラリー化する今回の研究成果は技術的新規性，優位性が保証されると考えている.
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