Overfill theory in canine and feline glomerular disease: mechanisms, biomarker, and therapyy

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K08056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Kagoshima University
• Principal Investigator: YABUKI AKIRA 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
• Research Collaborator: Ichii Osamu ; Yamato Osamu ; Kohyama Moeko ; Sawa Mariko
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: オーバーフィル / 糸球体疾患 / 犬 / 猫

Outline of Final Research Achievements

In this study, we analyzed the pathophysiological mechanism of glomerulonephropathy in dogs and cats. Twenty-four cases (17 dogs and 7 cats) were clinically diagnosed with glomerulonephropathy and received renal biopsy (or postmortem renal pathology). As the results, it was suggested that Overfill theory is a rare mechanism in the incidence of nephrotic syndrome in dogs and cats with glomerulonephropathy. The pathophysiological mechanism of all cases with nephrotic syndrome was considered as the classical Underfill theory. In addition, even in the same glomerular disease, the pathological progression mechanism is different between immune complex-mediated glomerulonephritis and non-immune complex-mediated glomerulonephropathy. This difference might be induced by the magnitude of proteinuria.

Free Research Field

獣医陣泌尿器病学、獣医臨床病理学

Academic Significance and Societal Importance of the Research Achievements

糸球体腎症は難治性の腎疾患であり、その治療法も限られている。糸球体腎症はヒトで多く発生する疾患であるが、犬や猫ではその病態がヒト異なっており、ヒトの治療法を簡単には外挿できない。そのため、犬および猫の動物種の特性を明らかにすることが本疾患の治療戦略には欠かせない。本研究は、重篤な臨床症状であるネフローゼ症候群の発生および進行メカニズムの一端を明らかにしたものであり、本疾患の治療戦略の開発に向けて重要な知見を寄与すると期待される。