Screening of drug target proteins for diabetic nephropathy by identification of ChREBP complex from renal mesangial cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K08606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: Yokoyama Atsushi 東北大学, 医学系研究科, 助教 (20572332)
• Research Collaborator: SHIMA hiroki ; SUGAWARA akira ; NORO erika
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 生化学 / 糖尿病 / 腎症

Outline of Final Research Achievements

In this research projecct, we focused on ChREBP, a DNA-binding transcription factor which is believed to be involved in diabetic nephropathy pathogenesis. To understand ChREBP-mediated transcriptional regulation, we tried to identify ChREBP-containing protein complex using renal mesangial cells. In this attempt, we identified several coregulator candidates for ChREBP and, we also identified cross-talk mechanisms between ChREBP and inflammation signals. To developing drugs targeting these factors might be promising strategy for diabetic nephropathy and other metabolic syndromes.

Free Research Field

生化学

Academic Significance and Societal Importance of the Research Achievements

本研究課題においては、糖尿病性腎症の発症に関わると考えられているChREBPという転写因子に着目しその転写活性を制御するメカニズムの解明を行った。その結果、転写制御に関わると考えられる候補因子を複数見出すことができた。これらの因子の解析と、これらを標的とした薬剤の開発は糖尿病性腎症をはじめとした生活習慣病の治療薬の開発へと繋がる可能性がある。