Infiltration of CD1a-positive dendritic cells and mucin core protein expression in gallbladder cancer

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K08650
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Saga University
• Principal Investigator: Kai Keita 佐賀大学, 医学部, 准教授 (60516540)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 胆嚢癌 / 樹状細胞 / CD1a / 予後因子 / ムチンコア蛋白

Outline of Final Research Achievements

We have focused on CD1a-positive dendritic cells (CD1a-DCs) infiltrating into gallbladder cancer (GBC) tissue and have analyzed the relationships between CD1a-DCs infiltration and clinicopathological factors including prognosis and expressions of mucin core proteins. We found that GBC could be divided into two subgroups. Namely, CD1a-DCs high group which contains many CD1a-DCs or CD1a-DCs low group which contains none or scant CD1a-DCs. CD1a-DCs high group showed favorable prognosis regardless of T- or N-factors. Furthermore, CD1a-DCs infiltration was powerful independent prognostic factor than distant metastasis in the analysis of overall survival. To clarify the mechanism of induction or differentiation CD1a-DCs in GBC tissue would contribute the development of new treatment (such as immunotherapy or molecular targeted therapy) for GBC.

Free Research Field

診断病理学

Academic Significance and Societal Importance of the Research Achievements

胆嚢癌組織中のCD1a陽性樹状細胞浸潤を解析することで、現行のステージングを超えた的確な予後予測実現の可能性がある。癌組織においてCD1a陽性樹状細胞が分化誘導されるメカニズムを解明することにより、進行胆嚢癌の新規治療法の開発 (免疫療法や分子標的療法) に繋がる可能性がある。