Analysis of parasitophorous vacuole membrane protein in hemoglobin transport and metabolism of malarial parasites

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K08760
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Kobe University
• Principal Investigator: Iriko Hideyuki 神戸大学, 保健学研究科, 准教授 (60346674)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: マラリア / 生殖母体 / 寄生胞膜

Outline of Final Research Achievements

Plasmodium parasites on erythrocytes utilize hemoglobin as a source of amino acid. Uptake and transport of hemoglobin by malarial parasites are carried out through parasitophorous vacuole membrane (PVM), but the molecular mechanism has not been elucidated. In this study, I focused on the PVM protein (ETRAMP family) of P. falciparum and analyzed the localization in the membrane structure involved in hemoglobin transport. In the result, ETRAMP10.3 was found to be localized to the PVM, cytostorm and hemoglobin transport vesicles, and to be an indicator of hemoglobin transport during gametocyte stage.

Free Research Field

寄生虫学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、マラリア原虫の赤血球寄生を支えるヘモグロビン輸送・代謝における寄生胞膜分子の重要性を示唆している。