2019 Fiscal Year Final Research Report
Development of diagnostic methods in interstitial pneumonia via surface markers of macophages
Project/Area Number |
16K08940
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Iwate Medical University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Keywords | 間質性肺炎 / 慢性閉塞性肺疾患 / 単球 / 表面マーカー |
Outline of Final Research Achievements |
We determined whether cellular phenotypes on circulating monocytes could be helpful for discriminating IPF from idiopathic nonspecific interstitial pneumonia (iNSIP). Using flowcytometer, we found that S100A9+CD163- cell rates in classical monocytes were significantly increased in IPF relative to iNSIP, and yielded the independent association with IPF in multivariate regression analyses and a receiver operating characteristic-area under the curve of 0.838 (95% CI [0.715-0.961], p < 0.0001) for the diagnoses. In addition, he ratio yielded a ROC-AUC value of 0.719 (95% CI = 0.567-0.871) for discrimination between smokers with normal lung functions and COPD patients. Our results demonstrated increased pro-inflammatory phenotypes in circulating classical monocytes in IPF and COPD, providing novel insights to elucidate their roles in the pathogenesis of these conditions.
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Free Research Field |
病態検査学 呼吸器病学
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Academic Significance and Societal Importance of the Research Achievements |
特発性間質性肺炎診断の補助診断として有用である。また喫煙者における早期COPD診断の補助診断に使用できる。
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