Development of diagnostic methods in interstitial pneumonia via surface markers of macophages

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K08940
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Iwate Medical University
• Principal Investigator: YAMASHITA MASAHIRO 岩手医科大学, 医学部, 助教 (10606685)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 間質性肺炎 / 慢性閉塞性肺疾患 / 単球 / 表面マーカー

Outline of Final Research Achievements

We determined whether cellular phenotypes on circulating monocytes could be helpful for discriminating IPF from idiopathic nonspecific interstitial pneumonia (iNSIP). Using flowcytometer, we found that S100A9+CD163- cell rates in classical monocytes were significantly increased in IPF relative to iNSIP, and yielded the independent association with IPF in multivariate regression analyses and a receiver operating characteristic-area under the curve of 0.838 (95% CI [0.715-0.961], p < 0.0001) for the diagnoses. In addition, he ratio yielded a ROC-AUC value of 0.719 (95% CI = 0.567-0.871) for discrimination between smokers with normal lung functions and COPD patients. Our results demonstrated increased pro-inflammatory phenotypes in circulating classical monocytes in IPF and COPD, providing novel insights to elucidate their roles in the pathogenesis of these conditions.

Free Research Field

病態検査学　呼吸器病学

Academic Significance and Societal Importance of the Research Achievements

特発性間質性肺炎診断の補助診断として有用である。また喫煙者における早期COPD診断の補助診断に使用できる。