2019 Fiscal Year Final Research Report
Development of RT-PCR methods detecting disease-associated antisense RNA
| Project/Area Number |
16K08984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
YAMANAKA YASUNARI 国立研究開発法人理化学研究所, 科技ハブ産連本部, 客員主管研究員 (90402859)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Keywords | アンチセンスRNA |
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| Outline of Final Research Achievements |
Long non-coding RNAs(lncRNAs) have widespread roles in regulating gene expression. Very few lncRNAs that regulate disease progression, are identified to associate with Hmgb2. Quantitative RT-PCR using original probe can successfully detect lncRNAs and can be expected to improve laboratory medicine.
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| Free Research Field |
臨床検査医学
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| Academic Significance and Societal Importance of the Research Achievements |
国産プローブを用いた定量PCR法は、既存の米国のTaqManプローブと同等の感度と特異度を得ることができた。これは我が国の遺伝子関連検査の向上に寄与すると期待される。
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