2019 Fiscal Year Final Research Report

A 3-week exercise-based interventional trial for fibromyalgia inpatients: using brain network change as an indicator of the effects

Research Project

PDF

Project/Area Number	16K09002
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Pain science
Research Institution	Naragakuen University (2019) Osaka Yukioka College of Health Science (2016-2018)
Principal Investigator	Fujita Nobuko 奈良学園大学, 保健医療学部, 准教授 (20709810)
Co-Investigator(Kenkyū-buntansha)	仙波恵美子大阪行岡医療大学, 医療学部, 教授 (00135691) 行岡正雄大阪行岡医療大学, 医療学部, 教授 (20513021) 寒重之大阪大学, 医学系研究科, 特任助教(常勤) (20531867) 柴田政彦奈良学園大学, 保健医療学部, 教授 (50216016) 高井範子大阪行岡医療大学, 医療学部, 教授 (60388668) 堀竜次森ノ宮医療大学, 保健医療学部, 教授 (70643592) 池田耕二大阪行岡医療大学, 医療学部, 准教授 (70709873) 高橋紀代大阪大学, その他部局等, 研究員 (80296714)
Project Period (FY)	2016-04-01 – 2020-03-31
Keywords	線維筋痛症 / 脳内ネットワーク / 疼痛 / うつ / 身体機能 / 包括的QOL
Outline of Final Research Achievements	We investigated the effects of a 3-week exercise-based intervention program for fibromyalgia inpatients on pain, physical and attention abilities, quality of living (QOL), resting-state functional connectivity by MRI and cerebral blood flow by fNIRS. We found that most patients showed improvements in fibromyalgia symptoms and anxiety/depression scores, but variable effects in pain intensity and cognitive aspects. Furthermore, changes of the functional connectivity between specific brain areas were observed after exercise intervention, and these changes of functional connectivity were correlated with improvements of fibromyalgia symptoms.
Free Research Field	線維筋痛症　運動療法　脳機能　姿勢制御
Academic Significance and Societal Importance of the Research Achievements	線維筋痛症(FM)の運動療法は従来の薬物療法に比べ、治療効果が高く、安全で経費が少ないことが知られており、運動の治療効果を科学的に立証し、運動療法を普及していくことで、長年FM症状に苦しむ患者や潜在的に存在するFM患者の重症化に歯止めをかけることができると考える。