Role of gut microbiome on pathophysiology of brain-gut interaction in irritable bowel syndrome

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K09227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: KANAZAWA Motoyori 東北大学, 医学系研究科, 准教授 (70323003)
• Co-Investigator(Kenkyū-buntansha): 鹿野 理子 東北大学, 医学系研究科, 大学院非常勤講師 (20344658) ; 村椿 智彦 東北大学, 医学系研究科, 助教 (70741007) ; 福土 審 東北大学, 医学系研究科, 教授 (80199249)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 過敏性腸症候群 / 腸内細菌 / 脳腸相関

Outline of Final Research Achievements

It has been unknown how the intestinal bacterial production of metabolites are associated with pathophysiology of irritable bowel syndrome (IBS). The aims of the present study were to investigate whether fecal bacterial metagenome function alters in IBS patients.
We found that the relative abundances of gut microbial composition were different between IBS patients and healthy controls (HC) and that the bacterial pathways for amino acid metabolism were more enriched in IBS compared with HC.
These findings suggest that altered amino acid metabolism of gut microbiome may contribute to pathophysiology of IBS.

Free Research Field

心身医学

Academic Significance and Societal Importance of the Research Achievements

腸内細菌の代謝機能の視点から有病率が高くストレス関連疾患の１つである過敏性腸症候群（IBS）における脳腸相関の病態を解明することによって、腸内環境に対するIBS治療法の確立に向けた新たな基盤を築くことができた。すなわち、IBS患者に対して腸内細菌叢の変化とその代謝機能の改善に焦点を当てた新たな治療法の開発が期待できるであろう。