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2018 Fiscal Year Final Research Report

Explorateive research of biomarkers for coronary microvascular dysfunction in the patients with vasospastic angina

Research Project

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Project/Area Number 16K09413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionTohoku University

Principal Investigator

Takahashi Jun  東北大学, 大学病院, 講師 (00375081)

Co-Investigator(Kenkyū-buntansha) 下川 宏明  東北大学, 医学系研究科, 教授 (00235681)
Research Collaborator Odaka Yuji  
Nihei Taro  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords冠攣縮性狭心症 / 微小血管型狭心症 / バイオマーカー
Outline of Final Research Achievements

We had two major findings in the present study. At first, we demonstareted that Rho-kinase activity in circulating leucocytes is a useful biomarker for not only diagnosis and disease activity assessment but also prognostic stratification of the patients with vasospastic angina (VSA). Second, we showed that plasma concentration of serotonin may be a novel biomarker for coronary microvascular dysfunction in patients with angina and unobstructive coronary arteries.

Free Research Field

循環器内科、虚血性心疾患

Academic Significance and Societal Importance of the Research Achievements

前述したバイオマーカーの発見は両者とも世界で初めてのことであり、それらバイオマーカーを利用することによって、冠攣縮性狭心症患者の中でも長期予後が不良であったり、微小血管障害を合併するなどのハイリスク患者を層別化することが可能となり、それら難治性冠攣縮における新たな治療戦略の確立につながることが期待される。

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Published: 2020-03-30  

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