左室収縮の保持された心不全に対する呼吸補助療法の有用性

2017 Fiscal Year Research-status Report

• Project/Area Number: 16K09447
• Research Institution: Fukushima Medical University
• Principal Investigator: 義久 精臣 福島県立医科大学, 医学部, 教授 (40448642)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 心不全

Outline of Annual Research Achievements

左室収縮の保たれた心不全(HFpEF)における病態と心不全予後の関係などについて検討し複数の論文化を行った。また、睡眠呼吸障害が動脈スティフネスに与える影響は左室駆出率の低下して心不全(HFrEF)とHFpEFにおいて異なることを検証し論文化した。現在、呼吸補助療法による心機能、血管機能、呼吸機能などについて検討を行っている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究の実施および論文化は順調に進行している。

Strategy for Future Research Activity

研究を継続し、症例数の増加、調査期間の延長にて結果の妥当性を向上させる。結果について多面的な検討を行っていく。

Research Products

• [Journal Article] Association between sleep-disordered breathing and arterial stiffness in heart failure patients with reduced or preserved ejection fraction (2018)
  • Author(s): Suzuki Satoshi、Yoshihisa Akiomi、Sato Yu、Watanabe Shunsuke、Yokokawa Tetsuro、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Kunii Hiroyuki、Nakazato Kazuhiko、Suzuki Hitoshi、Saitoh Shu-ichi、Ishida Takafumi、Takeishi Yasuchika
  • Journal Title: ESC Heart Failure Volume: 5 Pages: 284～291
  • DOI: 10.1002/ehf2.12273
  • Peer Reviewed / Open Access
• [Journal Article] Associations between acylcarnitine to free carnitine ratio and adverse prognosis in heart failure patients with reduced or preserved ejection fraction. (2018)
  • Author(s): Yoshihisa A, Watanabe S, Yokokawa T, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Journal Title: ESC Heart Failure Volume: 4 Pages: 360-364
  • DOI: 10.1002/ehf2.12176
  • Peer Reviewed / Open Access
• [Journal Article] Subclinical hypothyroidism is associated with adverse prognosis in heart failure patients. (2018)
  • Author(s): Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Watanabe S, Kanno Y, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Ishida T, Takeishi Y
  • Journal Title: Can J Cardiol Volume: 34 Pages: 80-87
  • DOI: 10.1016/j.cjca.2017.10.021.
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic ｖalue of high-sensitivity troponin T in chronic heart failure: an individual patient data meta-analysis. (2018)
  • Author(s): Aimo A, Januzzi JL, Vergaro G, Ripoli A, Latini R, Masson S, Magnoli M, Anand IS, Cohn JN, Tavazzi L, Tognoni G, Gravning J, Ueland T, Nymo SH, Rocca HP, Genis AB, Lupon J, Boer RA, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Tentzeris I, Tang WH, Grodin J, Passino C, Emdin M
  • Journal Title: Circulation Volume: 137 Pages: 286-297
  • DOI: 10.1161/CIRCULATIONAHA.117.031560.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Better clinical outcome with direct oral anticoagulants in hospitalized heart failure patients with atrial fibrillation. (2018)
  • Author(s): Yoshihisa A, Sato Y, Sato T, Suzuki S, Oikawa M, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 18 Pages: 11
  • DOI: 10.1186/s12872-018-0746-z
  • Open Access
• [Journal Article] Impact of nutritional indices on mortality in patients with heart failure. (2018)
  • Author(s): Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Ishida T, Takeishi Y:
  • Journal Title: Open Heart Volume: 5 Pages: e000730
  • DOI: 10.1136/openhrt-2017-000730.
  • Peer Reviewed / Open Access
• [Journal Article] Novel parameter to predict left ventricular filling pressure: product of log B-Type Natriuretic peptide and ratio of mitral inflow early and late diastolic filling velocities. (2018)
  • Author(s): Oikawa M, Kobayashi A, Wada K, Sato T, Suzuki S, Yoshihisa A, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y
  • Journal Title: J Card Fail Volume: 24 Pages: 29-32
  • DOI: 10.1016/j.cardfail.2017.10.008.
  • Peer Reviewed
• [Journal Article] Cardiopulmonary exercise testing as prognostic indicators: Comparisons among heart failure patients with reduced, mid-range and preserved ejection fraction. (2017)
  • Author(s): Sato T, Yoshihisa A, Kanno Y, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y
  • Journal Title: European Journal of Preventive Cardiology Volume: 24 Pages: 1979-87
  • DOI: 10.1177/2047487317739079
  • Peer Reviewed
• [Journal Article] Associations of acid suppressive therapy with cardiac mortality in heart failure patients. (2017)
  • Author(s): Yoshihisa A, Takiguchi M, Kanno Y, Sato A, Yokokawa T, Miura S, Abe S, Misaka T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Am Heart Assoc Volume: 6 Pages: e005110
  • DOI: 10.1161/JAHA.116.005110
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features in extremely elderly patients with heart failure. (2017)
  • Author(s): Yokokawa T, Yoshihisa A, Kanno Y, Sato T, Suzuki S, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Geriatrics & Gerontology International Volume: 17 Pages: 2194-2199
  • DOI: 10.1111/ggi.13060.
  • Peer Reviewed
• [Journal Article] Change of exhaled acetone concentration in a diabetic patient with acute decompensated heart failure. (2017)
  • Author(s): Yokokawa T, Ichijo Y, Houtsuki Y, Matsumoto Y, Oikawa M, Yoshihisa A, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Shimouchi A, Takeishi Y
  • Journal Title: Int Heart J Volume: 58 Pages: 828-830
  • DOI: 10.1536/ihj.16-556.
  • Peer Reviewed / Open Access
• [Journal Article] Decreased cardiac mortality with nicorandil in patients with ischemic heart failure. (2017)
  • Author(s): Yoshihisa A, Sato Y, Watanabe S, Yokokawa T, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 17 Pages: 141
  • DOI: 10.1186/s12872-017-0577-3.
  • Peer Reviewed / Open Access
• [Journal Article] Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus (2017)
  • Author(s): Yokokawa T, Sato T, Suzuki S, Oikawa M, Yoshihisa A, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Shimouchi A, Takeishi Y
  • Journal Title: BMC Cardiovasc Disord Volume: 17 Pages: 280
  • DOI: 10.1186/s12872-017-0713-0.
  • Peer Reviewed / Open Access
• [Journal Article] Liver stiffness assessed by Fibrosis-4 index predicts mortality in patients with heart failure. (2017)
  • Author(s): Sato Y, Yoshihisa A, Kanno Y, Watanabe S, Yokokawa T, Abe S, Misaka T, sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Takeishi Y
  • Journal Title: Open Heart Volume: 4 Pages: e000598
  • DOI: 10.1136/openhrt-2017-000598.
  • Peer Reviewed / Open Access
• [Presentation] Chronotropic incompetence is not associated with prognosis in heart failure patients with preserved ejection fraction and atrial fibrillation (2017)
  • Author(s): Sato T, Yoshihisa A, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Association between anatomical situation surrounding the esophagus and the prevalence of transmural thermal injury after pulmonary vein isolation with cryoballoon ablation. (2017)
  • Author(s): Matsumoto Y, Kaneshiro T, Nodera M, Kamioka M, Suzuki H, Yoshihisa A, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Associations between plasma zinc and mortality in heart failure patients. (2017)
  • Author(s): Kanno Y, Yoshihisa A, Kiko T, Kimishima Y, Sato Y, Watanabe S, Tatsumi M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Associations between testosterone levels and mortality in male patients with heart failure. (2017)
  • Author(s): Suzuki S, Yoshihisa A, Kiko T, Kimishima Y, Sato Y, Watanabe S, Kanno Y, Tatsumi M, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Saitoh S, Ishida T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Presentation] Clinical significance of get with the guidelines-heart failure risk score in heart failure patients after hospitalization. (2017)
  • Author(s): Suzuki S, Yoshihisa A, Sato Y, Kanno Y, Watanabe S, Abe S, Sato T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Ishida T, Takeishi Y.
  • Organizer: Scientific Sessions of American Heart Association 2017
• [Remarks] 福島県立医科大学 研究者詳細
  • URL: http://www.fmu.ac.jp/kenkyu/html/725_ja.html