4 gene signature will predict the recurrence for stage I lung carcinomas.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09561
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Noro Rintaro 日本医科大学, 医学部, 講師 (50366738)
• Co-Investigator(Kenkyū-buntansha): 清家 正博 日本医科大学, 医学部, 教授 (30366687)
• Research Collaborator: Curtis Harris
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 再発予測

Outline of Final Research Achievements

Surgery with curative intent is the standard treatment for stage I lung adenocarcinoma. However, disease recurrence occurs in a third of patients, and additional adjuvant chemotherapy will be needed for lung carcinomas with high risk for recurrence. There are no validated molecular methods that prospectively identify patients with surgically resected lung carcinoma with early stage at high risk for recurrence. We established the diagnostic system for analyzing 4 gene signature including DLD1, XPO1, BRCA1 and HIF1A, HOXA9 methylation, pathological finding with vascular invasion, ACTN4 activity. We are analyzing how these modality would be able to predict the recurrence with more precision. These system would prove the prognosis for lung carcinomas with early stage.

Free Research Field

呼吸器内科

Academic Significance and Societal Importance of the Research Achievements

肺癌Ⅰ期、特にIA期であっても術後化学療法が必要な予後不良群や不必要な予後良好群が存在し、正確に予測できる再発予測マーカーの同定が必要である。よって新しい再発予測マーカーを構築する。この診断システムにより、術後化学療法を行う必要がある再発高リスク群患者の予後の向上や、不必要な化学療法を行わないことにより、再発低リスク患者のQOLの向上も図ることができる。