Biological role of FGF23-Klotho signal in Ca-P metabolism and immu sysytem

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09651
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Mima Toru 和歌山県立医科大学, 医学部, 准教授 (30373517)
• Co-Investigator(Kenkyū-buntansha): 重松 隆 和歌山県立医科大学, 医学部, 教授 (30187348)
• Research Collaborator: Yashiro Mitsuru
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: FGF23 / Klotho / エリスロポエチン / B細胞 / ADAM17

Outline of Final Research Achievements

It has been that FGF23 has played an important role in Ca-P metabolism. Newly, We found that FGF23 were crosstalk with erythropoietin in renal epitherial cells. Moreover, number of Klotho positive B cells was decrease in patients with hemodialysis. This may be caused for immunocompromised host of the patients with hemodialysis. We found that One of the causes for decrease of Klotho positive B cells was digested by ADAM17, which was activated in the patients with hemodialysis.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

FGF23とエリスロポエチンは腎不全病態において重要な役割を果たしている。その両者が腎尿細管細胞で相互作用していることは、新たな治療法の開発や創薬のシーズとなる。さらに、B細胞に発現するKlothoの低下が透析患者の易感染性に結び付く可能性は、透析患者の死因の多くを占める感染症について新たな治療法や創薬のシーズとなり医学的意義は大きいい。これらを基に、透析患者の易感染性を完全できれば感染症に費やす医療費の削減も期待でき社会的にも意義は大きい。