Interracial study of pathogenesis in type 1 diabetes by using a novel autoantigen INS-IGF2.

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K09769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka Medical College
• Principal Investigator: Kanatsuna Norio 大阪医科大学, 医学部, 助教 (80738360)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 1型糖尿病 / INS-IGF2 / 膵島関連自己抗体

Outline of Final Research Achievements

The aim of this study was to determine INS-IGF2 autoantibodies in Japanese type 1 diabetes patients and controls, and compare with Swedish type 1 diabetes patients to clarify that INS-IGF2 autoimmunity contributes to type 1 diabetes.
As a result, the levels of INS-IGF2 autoantibodies in Japanese type 1 diabetes patients were lower than in Japanese controls, although in Swedish type 1 diabetes patients were higher than in Swedish controls in previous reports.

Free Research Field

代謝学

Academic Significance and Societal Importance of the Research Achievements

日本人とスウェーデン人では1型糖尿病の発症メカニズムの一部が異なっている可能性を示す大変興味深い結果であり、今後、INS-IGF2に関するさらなる究明が必要と考えられた。今回の測定結果については、小集団に分類する、他の膵島関連自己抗体と抗INS-IGF2自己抗体との関係について調べる等、別の解析を追加することで、より詳細な検討を行う予定である。