2018 Fiscal Year Final Research Report
myeloid derived suppressor cells as a novel immune therapy
| Project/Area Number |
16K09893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kobe University |
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Principal Investigator |
Morinobu Akio 神戸大学, 医学研究科, 准教授 (10294216)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 関節リウマチ / リウマチ肺 / 樹状細胞 / 骨髄由来抑制細胞 |
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| Outline of Final Research Achievements |
In order to clarify the role for meyloid derived suppressor cells (MDSC) in ILD ion SKG model mice, we examined the function and origin of lung-infiltrating MDSC and MDSC. First we identified MDSC and novel tolerogenic DC-like cells in the inflamed lungs. Next we isolated these populations and co-cultured with T cells to find that both of these cells are immuno-suppressive. The latter cells were induced from total lung cells and lung MDSCs in a TGFb dependent manner.Also adoptive transfer of the latter cells ameriolated the progression of ILD.
Our findings will pave the way to a novel immunosuppressive therapy and cell-based therapies in the future.
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| Free Research Field |
膠原病リウマチ学
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| Academic Significance and Societal Importance of the Research Achievements |
この結果は、炎症部位においては新たな免疫抑制機序が働いていることを示し、新規治療法の開発につながる。
今後はヒトにおいて病勢との関連や、細胞治療への応用のための研究が期待される。
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