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2018 Fiscal Year Final Research Report

Stress response evaluation and novel therapy development in advanced cardiac and pulmonary diseases in children

Research Project

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Project/Area Number 16K10067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

TSUKAHARA Hirokazu  岡山大学, 医歯薬学総合研究科, 教授 (90207340)

Co-Investigator(Kenkyū-buntansha) 馬場 健児  岡山大学, 大学病院, 准教授 (40721767)
大月 審一  岡山大学, 大学病院, 教授 (90294454)
Research Collaborator MIYAHARA Hiroyuki  
WASHIO Yosuke  
Yoshimoto Junko  
Yashiro Masato  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywordsアルギニン代謝 / 一酸化窒素 / 川崎病 / 血管内皮機能 / 酸化ストレス / シトリン欠損症 / 生体マーカー / レドックス制御
Outline of Final Research Achievements

We performed clinical and translation studies related to advanced cardiac and pulmonary pathologies on the high-class clinical and experimental research backgrounds in Okayama University Hospital. Especially, we took special attention to vascular endothelial function/dysfunction, oxidative/nitrosative stress (redox regulation/dysregulation), nitric oxide production and arginine metabolism in the present work. Thus, we sought to develop adequate management strategies and novel therapeutic approaches for advanced cardiac and pulmonary diseases in children.

Free Research Field

ストレス応答学

Academic Significance and Societal Importance of the Research Achievements

本研究成果に基づいてさらに知見を深めることによって、小児心臓・肺領域の急速進行性病態では進行抑制、完全治癒、慢性遷延性病態では寛解導入、合併症抑止が導かれ、ひいては、患児の日常生活、学校生活、将来生活を含めたQuality of Life(QOL)を向上させる方略が開発されることが期待された。さらに、小児医療の質の向上と医療費の節減に貢献することも期待された。

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Published: 2020-03-30  

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