2018 Fiscal Year Final Research Report
MR Visualization of Treatment Margins Surrounding Liver Cancer in Radiotherapy
| Project/Area Number |
16K10332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Yamaguchi Masayuki 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (90450577)
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| Research Collaborator |
Furuta Toshihiro
Ohnuki Kazunobu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 核磁気共鳴画像（MRI） / 肝がん / 放射線治療 / 画像診断 / 造影剤 |
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| Outline of Final Research Achievements |
We invented an MRI technique that can clearly visualize liver cancers and surrounding liver tissues in the early period after radiotherapy had started. We utilized clinically-approved iron oxide-based contrast media. This technique may reduce the risk of local recurrence of cancer lesions as well as the risk of radiation-induced liver damage when using with image-guided radiotherapy. In this project, we investigated the mechanism of the visualization from cell-biological point-of-view and also performed preclinical experiments using an ultra-high field MRI system to show the feasibility of the technique in vivo.
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| Free Research Field |
MRI診断技術の開発
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| Academic Significance and Societal Importance of the Research Achievements |
放射線照射によって、本来細胞が持つ、酸化鉄を分解し排泄する機能に異常が生じることを初めて明らかにし、その分解や排泄の速度を調べる手法を考案した点で学術的な意義が大きい。肝がんの放射線治療成績の向上につながる知見が得られた点は、将来の患者利益につながる。また、酸化鉄製剤の新しい使用法を見出した点で、将来、関連領域の創薬につながる可能性もあり、社会的にも意義がある研究と考えられる。
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