PET molecular imaging of proliferation in head and neck cancer

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10351
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagawa University
• Principal Investigator: Nishiyama Yoshihiro 香川大学, 医学部, 教授 (50263900)
• Co-Investigator(Kenkyū-buntansha): 山本 由佳 香川大学, 医学部, 准教授 (30335872) ; 豊原 潤 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50425659) ; 星川 広史 香川大学, 医学部, 教授 (70294767) ; 羽場 礼次 香川大学, 医学部附属病院, 准教授 (90304584)
• Research Collaborator: MITAMURA Katsuya
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: PET / 頭頸部癌 / C-11 4DST

Outline of Final Research Achievements

A new radiopharmaceutical, C-11 4DST, has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to evaluate the usefulness of C-11 4DST PET/CT for assessment of disease control of chemoradiotherapy for head and neck squamous cell carcinoma, in comparison with F-18 FDG PET/CT.
Increased C-11 4DST and F-18 FDG uptake in primary lesion was visible. SUVafter values from C-11 4DST PET/CT in relapse-free group were significantly lower than those in relapse group. The percent change values from C-11 4DST PET/CT in relapse-free group were significantly higher than those in relapse group. Using F-18 FDG PET/CT, SUVafter and percent change were not significant differences between relapse-free and relapse groups.

Free Research Field

PET

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍の特徴として無制限な自律性増殖があげられ、細胞増殖つまり核酸代謝をターゲットとした分子イメージングが注目されている。私どもの施設ではDNA合成イメージング剤としてC-11 4DST PETを行っている。C-11 4DST PETで頭頸部癌の陽性描画は可能である。頭頸部癌の核酸代謝を非侵襲的に評価する事で、予後評価や腫瘍再発評価における有用性が示唆された。