Basic researches about the efficacy of a tryptophan metabolite in the pulmonary radiofrequency ablation effect measurement

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K10354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Miyazaki
• Principal Investigator: Nakada Hiroshi 宮崎大学, 医学部, 講師 (00363599)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 肺腫瘍 / ラジオ波治療 / 家兎

Outline of Final Research Achievements

It has been identified that in radiofrequency ablation therapy for lung tumors, inflammatory changes and hemorrhage are intermingled in the marginal zone after ablation, which makes it difficult to determine the therapeutic effect. We hypothesized that the combined use of anti-inflammatory drug (tranilast) administration would solve the above problems, and conducted animal experiments using rabbit lungs.Immunohistological study was performed by dividing into the tranilast administration group and the placebo administration group.
As the pharmacological action of tranilast, fibrosis-suppressing effect and vascular permeability / angiogenesis-suppressing effect are known.
In the evaluation of immunostaining, although there was no significant　difference, vascular endothelial growth factor and tumor immunosuppressive cytokine production tended to be suppressed in the tranilast group.

Free Research Field

内科系臨床医学放射線科学

Academic Significance and Societal Importance of the Research Achievements

肺腫瘍に対するラジオ波焼灼術の治療法に関しては多くの研究報告がなされているが、本研究のような効果判定に関連した研究報告は少ない。また、通常術後に肺組織を摘出することが困難な患者が治療対象となるため、焼灼後の組織学的所見を詳細に検討した報告も少なく、動物実験を用いた本研究がその代替となり得る。本研究の結果、抗炎症薬が焼灼域周囲の過剰な二次性炎症や出血を抑制する傾向が認められ、治療効果判定の妨げとなるCT検査での高吸収域を早期に縮小させる効果が期待される。これは腫瘍再発の早期発見に寄与し、迅速な追加焼灼術が可能となる点に意義がある。