2020 Fiscal Year Final Research Report

To elucidate the prognostic marker using amino acid PET imaging and signal transduction factors in brain tumor patients

Research Project

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Project/Area Number	16K10368
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	Kindai University
Principal Investigator	KAIDA HAYATO 近畿大学, 医学部, 講師 (40299425)
Co-Investigator(Kenkyū-buntansha)	加藤天美近畿大学, 医学部, 教授 (00233776) 河原明彦久留米大学, 大学病院, 医療技術員 (00469347) 村上卓道神戸大学, 医学研究科, 教授 (20252653) 服部聡大阪大学, 医学系研究科, 教授 (50425154) 石井一成近畿大学, 医学部, 教授 (50534103) 伊藤彰彦近畿大学, 医学部, 教授 (80273647)
Project Period (FY)	2016-04-01 – 2021-03-31
Keywords	脳腫瘍 / アミノ酸イメージング / 癌シグナル伝達因子
Outline of Final Research Achievements	The aim of this study is to reveal the correlation and prognostic factors among 11C-methionine (MET) uptake and signal transduction factors and to investigate the pathological relationship between amino acid metabolism and tumor cell proliferation in glioma patients undergoing both PET/CT and operation. Our data showed that MET uptake in glioma had positive correlation with L-type amino acid transporter-1 (LAT-1) and that MET uptake in glioma have potential role in predicting both the degree of malignancy and epidermal growth factor receptor (EGFR). Our data also suggest that LAT-1 expression may be related with tumor hypoxia.
Free Research Field	腫瘍核医学
Academic Significance and Societal Importance of the Research Achievements	過去にMET集積と細胞増殖シグナル伝達因子、脳腫瘍の腫瘍増殖の相関性を検討した報告は非常に少ない。MET集積評価法とシグナル伝達因子の関係が明らかになれば、治療後再発の可能性が高いリスク患者の層別化や化学療法や術後補助療法の決定にも役立つ可能性がある。また、アミノ酸代謝と脳腫瘍増殖の病理学的関係や腫瘍へのMET集積機序の解明の一助になりうるかもしれない。