Elucidation and control of the microemviroment of pancreatic cancer

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10600
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Saga University (2017-2018); Kyushu University (2016)
• Principal Investigator: Manabe Tatsuya 佐賀大学, 医学部, 准教授 (60546464)
• Co-Investigator(Kenkyū-buntansha): 宮坂 義浩 九州大学, 大学病院, 助教 (40507795) ; 森山 大樹 九州大学, 大学病院, 准教授 (70586859) ; 江口 大樹 九州大学, 医学研究院, 共同研究員 (90726390) ; 池永 直樹 九州大学, 医学研究院, 共同研究員 (90759755)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 膵癌 / 膵癌微小環境 / 治療誘導性secretome / 治療抵抗性

Outline of Final Research Achievements

Secretome or activity of stromal remodeling may cause reftactory pancreatic cancer. The system of microenvironment around pancreatic cancer was examined regarding therapy-inducible secretome. Using our established microenvironment model, several secretomes affecting cancer invasion and migration were identified. In the future, secretome affecting treatment resistance would be identified as a final goal.

Free Research Field

腫瘍学、外科学

Academic Significance and Societal Importance of the Research Achievements

今回の検討で癌の浸潤、遊走に関わるsecretome因子が複数同定できているので、治療抵抗性に関わるsecretome因子の同定を勧めていき、新たな治療戦略の一助になることを期待する。