2018 Fiscal Year Final Research Report
Analysis of cancer metastasis and invasion mechanism using a new lung adenocarcinoma cell line.
| Project/Area Number |
16K10689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 裕康 北里大学, 医学部, 助教 (30769831)
内藤 雅仁 北里大学, 医学部, 助教 (50648730)
三窪 将史 北里大学, 医学部, 助教 (90723940)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 肺腺癌 / 微乳頭構造 / 細胞株 / 転移 / 浸潤 |
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| Outline of Final Research Achievements |
Primary lung adenocarcinomas with a micropapillary pattern (MPP) are characterized by more frequent and pronounced vascular invasion, higher incidence and more advanced lymph node involvement, and poorer prognosis than papillary adenocarcinomas without an MPP. Here we established a new lung cancer cell line, named KU-Lu-MPPt3, featuring micropapillary structure from a patient with adenocarcinoma with MPP. We found some genes associated with cancer metastasis and invasion.
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| Free Research Field |
呼吸器外科
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| Academic Significance and Societal Importance of the Research Achievements |
新規細胞株を利用して,これまで成し得なかった解析(転移モデル動物の作成, 浸潤・転移に関与する因子の網羅解析等)が可能となり, 肺癌の早期診断や治療計画を立てる際の判断材料として有用なものとなるのみならず, 新たな分子標的治療薬や免疫療法といった新規治療開発にも寄与できる可能性が非常に高く, 社会的貢献度も高い.
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