2018 Fiscal Year Final Research Report
Investigation of mechanisms of rapture in cerebral aneurysm and research of its biomakers
Project/Area Number |
16K10718
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
umemura kazuo 浜松医科大学, 医学部, 教授 (40232912)
|
Research Collaborator |
HOKAMURA Kazuya
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Keywords | 脳動脈瘤 / MRI / 動物モデル |
Outline of Final Research Achievements |
The aim of this study is to establish animal model of cerebral aneurysm and to investigate its mechanisms using the animal model. Using 3T-MRI and coil for mouse head, we can image the arteries in mouse brain. In high cholesterol mice, the rapture of aneurysm increased rather than that in normal cholesterol mice. In plasminogen-knockout mice, the rapture of aneurysm reduced rather than that in control mice. This suggests that plasmin may be related with the rapture of aneurysm.
|
Free Research Field |
循環薬理学、脳循環
|
Academic Significance and Societal Importance of the Research Achievements |
口腔細菌と全身疾患は、古くから報告されているが、そのメカニズムは不明なものが多い。我々がこれまでに証明してきた高病原性う蝕原因菌と頭蓋内出血との関連性の解明やそのメカニズムの解析は口腔細菌と全身性疾患を考える上で1つの道筋を付ける研究と位置づけられる。今までにはない研究の切り口やアイディアが独創的で斬新である。脳動脈瘤の破裂に関する原因はすべてが解明されているわけではない。この高病原性う蝕原因菌が脳動脈瘤破裂の原因の1つであれば、脳動脈瘤破裂の予防や治療に大きく貢献できる。
|