2018 Fiscal Year Final Research Report
Analysis of serum biomarkers in patients with spinal ossification
Project/Area Number |
16K10815
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | University of Toyama |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
北島 勲 富山大学, 大学院医学薬学研究部(医学), 教授 (50214797)
箭原 康人 富山大学, 附属病院, 医員 (60456390)
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Research Collaborator |
YASUDA taketoshi
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Keywords | 脊椎脊髄病学 / 脊柱靭帯骨化症 / 骨化関連因子 |
Outline of Final Research Achievements |
We have investigated the serum biomarkers which might be related to the pathology of spinal ossification. Hyper-sensitive C-reactive protein (hs-CRP) in patients with the spinal ossification was higher than that in the control. Hs-CRP had a positive correlation with the progression of the spinal ossification. Serum inorganic phosphate (IP) was lower in patients with the spinal ossification, compared to the control. IP had a negative correlation with the extent of the spinal ossification. Serum FGF-23 was higher in patients with the spinal ossification. Based on these studies, we wrote a review paper regarding the relationship between the serum biomarkers and spinal ossification. These results are important to understand the pathology of spinal ossification.
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Free Research Field |
脊椎脊髄病学
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Academic Significance and Societal Importance of the Research Achievements |
脊柱靭帯骨化症は原因不明の疾患である。本研究はこの病因についてバイオマーカーを用いて検討し、以下の2つの知見を得た。1)脊柱靭帯骨化には炎症が関与し、特に骨化巣の伸展と正の相関があること、2)脊柱靭帯骨化では血清リン値が低下し、骨化巣の広がりと負の相関があること。またこれらのデータを基に文献的にレビューを行い、脊柱靭帯骨化症に関わるバイオマーカーを調べまとめた。以上の結果は脊柱靭帯骨化症の病因の解明のみならず、治療の糸口を探るために重要であると考えられた。
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