The development of new agents for the interstital cystitis / bladder pain syndrome base on gene profile

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Shinshu University
• Principal Investigator: Ogawa Teruyuki 信州大学, 学術研究院医学系, 准教授 (90467142)
• Co-Investigator(Kenkyū-buntansha): 今村 哲也 信州大学, 学術研究院医学系, 助教 (00467143) ; 石塚 修 信州大学, 学術研究院医学系, 教授 (20184541) ; 永井 崇 信州大学, 学術研究院医学系(医学部附属病院), 助教 (50514353) ; 平形 志朗 信州大学, 学術研究院医学系, 助教 (90749475)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 間質性膀胱炎 / ケモカイン

Outline of Final Research Achievements

Interstitial cystitis/bladder pain syndrome (IC/BPS) is one of the refractory diseases, which induces urinary frequency and bladder pain. The pathophysiology is unknown, therefore it is difficult to treat. We previously reported that genes related to inflammation and immune mechanism are highly associated with the pathogenesis of IC/BPS, therefore we planned to establish the rat cystitis models which express the same gene profile in the bladder. It is considered that the models are important to evaluate the efficacy of agents for treatment of IC/BPS. We found that rats which were locally irradiated to the bladder express the almost same gene profile as that of the human IC/BPS. In conclusion, the models are useful for the future research for the treatment of IC/BPS.

Free Research Field

排尿生理学

Academic Significance and Societal Importance of the Research Achievements

ヒト間質性膀胱炎の遺伝子発現と類似した動物モデルを作成することができた。
今後はそのモデルにおいて薬物治療を行うことで、病態を改善することが可能か、排尿機能ならびに組織学的に検討することで、今後の治療の基礎になると思われる