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2018 Fiscal Year Final Research Report

The analysis of function of the flavonoids which is active on the fertility rate of IVF.

Research Project

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Project/Area Number 16K11075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNagasaki International University

Principal Investigator

Tanaka Hiromitsu  長崎国際大学, 薬学部, 准教授 (10263310)

Research Collaborator Goshima Naoki  
Tsujimura Akira  
Miygawa Yasushi  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords不妊症 / 精子 / 精子形成 / 生殖細胞 / 生薬 / 甘草 / 精巣
Outline of Final Research Achievements

We have analyzed the mechanism of an increase in fertilization rate of Isoliquiritigenin and Formononetin extracted from licorice, when added to artificial insemination medium.
As a result, it was thought that these molecules passed through the cell membrane and reacted to sperm, affecting the motility and maturation of the sperm after ejection, and improving the fertilization rate. We have completed the conditions for identification of the proteins associated with Isoliquiritigenin and Formononetin in sperm by using protein arrays.

Free Research Field

アンドロロジー

Academic Significance and Societal Importance of the Research Achievements

不妊症治療や優良な家畜の安定的な生産と希少動物の保護などのために、効率的な人工授精が望まれている。本研究では、甘草から抽出した受精率に効果的が認められるイソリキリチゲインやホルモノネチンの精子に対する作用機序について解析を進めた。植物成分が動物の体内に取り入れられ、生理活性物質として作用し、これら分子の食物としての安全性について解析を進め、人工授精の改良に貢献できた。

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Published: 2020-03-30  

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