Tissue augmentation and remodeling of the eustachian tube by using dedifferentiated fat cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11199
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nihon University
• Principal Investigator: OSHIMA Takeshi 日本大学, 医学部, 教授 (40241608)
• Co-Investigator(Kenkyū-buntansha): 松崎 洋海 日本大学, 医学部, 准教授 (00451328)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 耳管開放症 / 中耳炎

Outline of Final Research Achievements

The aim of the present study was the establishment of treatments for eustachian tube closing failure by transplantation of dedifferentiated fat cells (DFAT) into the eustachian tube. In this study, an animal model for the eustachian tube closing failure could be developed by the mandibular neurectomy. Mandibular nerve resection in rats may be an effective method for generating an animal model of the eustachian tube disorder. It was suggested that this rat model may be useful for verifying new treatments for the eustachian tube disorder.

Free Research Field

耳鼻咽喉科学

Academic Significance and Societal Importance of the Research Achievements

耳管閉鎖障害は真珠腫性中耳炎をはじめとする難治性中耳疾患の重要な危険因子である。しかも、その有症率は高く、聴覚障害の大きな原因の一つとなっており、国民衛生上からも看過できない。しかし、これまで耳管閉鎖障害については信頼のおける適切なモデル動物が存在しなかった。本研究では再現性良く下顎神経を切断することにより耳管閉鎖障害の動物モデルの作製に成功した。今後はこれを用いて耳管障害の診断、治療、予防のための研究の発展が期待できる。