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2019 Fiscal Year Final Research Report

Research in the excitatory synaptic transmission during critical period of feeding

Research Project

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Project/Area Number 16K11488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

Nakamura Shiro  昭和大学, 歯学部, 准教授 (60384187)

Co-Investigator(Kenkyū-buntansha) 井上 富雄  昭和大学, 歯学部, 教授 (70184760)
Project Period (FY) 2016-04-01 – 2020-03-31
Keywords生後発達 / 摂食行動 / 閉口筋運動ニューロン / シナプス伝達 / グルタミン酸性受容体 / 開口筋運動ニューロン
Outline of Final Research Achievements

We electrophysiologically investigated the developmental nature of glutamatergic synaptic transmission to the jaw-closing and jaw-opening motoneurons to elucidate the role of glutamatergic receptor functions in the regulation of feeding. The synaptic inputs mediated by NMDA receptors containing NR2A and NR2B subunits to the jaw-closing motoneurons decreased with postnatal age. In contrast, there were no differences of NMDA receptor-mediated synaptic inputs to the jaw-opening motoneurons throughout the postnatal period. These results suggest that the NMDA receptor-mediated synaptic inputs alter during postnatal period, which may contribute to the developmental transition of feeding behavior from suckling to mastication.

Free Research Field

口腔生理学

Academic Significance and Societal Importance of the Research Achievements

本研究で明らかとなった、顎筋運動ニューロンにおけるグルタミン酸性シナプス伝達の生後発育変化は、吸啜から咀嚼への転換に重要な役割を果たしている可能性が考えられる。今回の基礎データは、摂食行動の臨界期制御機構の一端が明らかになっただけでなく、自閉症等の発達障害児で問題となる摂食障害の発症機序の解明にもつながり、歯科医学の分野だけでなく小児医学・生涯発達学などの多くの分野に貢献することができる。さらにNMDA受容体サブユニットをターゲットとした摂食障害の治療法開発につながるという波及効果も期待できる。

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Published: 2021-02-19  

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