2018 Fiscal Year Final Research Report
Establish of molecullar biological strategy to MRONJ by glucose metabolism
| Project/Area Number |
16K11607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 骨代謝 / 糖代謝 / MRONJ / 歯科インプラント |
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| Outline of Final Research Achievements |
MRONJ,which proceeds with dental treatment,is a major problem for osteoporosis-treated patients who are receiving bisphosphonate (BP). We focused on the relationship between bone metabolism and general glucose metabolism, and aimed to clarify the effect of BP on jaw bone healing delay after tooth extraction using a diabetes drug. Three-dimensional structural evaluation of the jaw bone after tooth extraction showed significant healing improvement of the tooth extraction socket in the experimental group. Furthermore, when the necrotic bone area was evaluated, the experimental group showed a significantly lower value. These results suggest that the risk of MRONJ for tooth extraction and implant treatment can be controlled by drug therapy.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
近年，BP 製剤とは異なる作用機序により骨吸収を抑制する薬剤でも，同頻度で顎骨壊死が発症するとの報告がある．BP 製剤自体の問題でなく，それらが持つ，骨吸収抑制作用に起因すると推測される．顎骨壊死の詳細な機序については，未だ明らかにされていないが，本研究で糖代謝の関連性が判明すれば，MRONJ の病態解析，新規骨吸収阻害創薬が可能となり，インプラント治療に限らず，BP 製剤がもたらす歯科治療への弊害を軽減することが期待できる．
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