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2018 Fiscal Year Final Research Report

Development of specific molecular target therapy for oral cancer using new drug delivery system

Research Project

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Project/Area Number 16K11698
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTohoku University (2017-2018)
Kyushu Dental College (2016)

Principal Investigator

IWANAGA KENJIRO  東北大学, 歯学研究科, 助教 (20448484)

Co-Investigator(Kenkyū-buntansha) 西原 達次  九州歯科大学, 歯学部, 特任教授 (80192251)
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords癌 / ソノポレーション / マイクロバブル
Outline of Final Research Achievements

Sonoporation is a drug and gene delivery system using ultrasonication that allows the intracellular delivery of foreign molecules that cannot enter cells under normal conditions.In this study, we developed anti-epidermal growth factor receptor (EGFR) antibody-conjugated Microbubbles (EGFR-MBs) and evaluated their capacity to enhance anti-cancer drug toxicity in vitro and in vivo. Bleomycin delivery using sonoporation with EGFR-MBs was significantly more toxic to the cells compared with the other groups.We next examined the effect of EGFR-MBs in a murine squamous cell carcinoma model. Bleomycin delivery by sonoporation with EGFR-MBs exhibited remarkable antitumor activity.
We focused novel platinum nanoparticles-conjugated latex beads, platinum nanocomposite(PtNCP) beads, and investigated the possibility to incorporate novel anti-cancer effect of these combined nanoparticles. PtNCP beads treatment suppressed tumor growth and identified increasing pathological necrotic areas, in vivo.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

舌癌などは、表層から超音波を当てることができ,ソノポレーション法を用いる部位として適している.抗EGFR抗体修飾マイクロバブルは表面が水溶性ポリエチレングリコールで修飾されているため,肝臓などを中心とする細網内皮系組織の貪食細胞に処理されず,血中に長時間循環滞留することができる.バブルに抗EGFR抗体を結合させることにより,より選択的に癌局所へ抗癌物質を集積することができる.これらのバブルを用いれば,ターゲットとなる癌組織にバブルを集積させ,体外からの超音波診断とともに,治療用超音波エネルギーで,非侵襲的に抗癌剤を導入できる.口腔癌の治療を始め,様々な難治性疾患の治療に応用可能である.

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Published: 2020-03-30  

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