2021 Fiscal Year Final Research Report
Involvement of anesthetics in axon guidance of regenerating neurons
| Project/Area Number |
16K11753
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokushima Bunri University (2017-2021)
The University of Tokushima (2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
里村 一人 鶴見大学, 歯学部, 教授 (80243715)
舘原 誠晃 鶴見大学, 歯学部, 講師 (90380089)
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| Project Period (FY) |
2016-04-01 – 2022-03-31
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| Keywords | 神経再生 / 麻酔薬 / 軸索ガイダンス |
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| Outline of Final Research Achievements |
We investigated the effects of general anesthetics, which are reported to have neurotoxic or neuroprotective effects, on regenerating neurons induced from bone marrow mesenchymal stem cells. Propofol, a commonly used general anesthetic, mildly enhanced neurite outgrowth in regenerating neurons at low concentrations, but inhibited it at higher concentrations. Pressure-loaded regenerating neurons showed inhibition of neurite outgrowth but did not lead to cell death.
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| Free Research Field |
歯科麻酔学
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| Academic Significance and Societal Importance of the Research Achievements |
神経再生の臨床応用が活発に進んでいる。臨床において、iPS 細胞や組織幹細胞から分化誘導した神経細胞の患者への移植は全身麻酔法下に行われることになり、神経再生医療に麻酔薬の使用は避けられない。そこで、安全な神経再生医療の実現に向けて、再生神経細胞に対する麻酔薬や軸索ガイダンス因子の作用、および移植後の圧負荷環境に対する再生神経細胞の挙動を把握しておくことは極めて重要である
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