Planning of a strategy for general anesthesia targeting good wound healing after oral and maxillofacial surgery

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K11764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: ICHINOHE Tatsuya 東京歯科大学, 歯学部, 教授 (40184626)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 組織血流量 / 組織酸素分圧 / 組織酸素消費量 / 組織酸素代謝

Outline of Final Research Achievements

Redistribution may occur between skin/mucosa and other oral tissues, but not between the tissues supplied by external carotid artery and those by internal carotid artery during remifentanil administration. Remifentanil reduces oral tissue oxygen consumption and thereby proportionally reduces oral tissue blood flow. As a result, oral tissue oxygen tension should be kept unchanged. Changes in arterial carbon dioxide tension do not affect oral tissue oxygen tension during remifentanil administration, and it is suggested that good oxygen metabolism in oral tissues should be maintained during remifentanil administration.

Free Research Field

歯科麻酔学

Academic Significance and Societal Importance of the Research Achievements

顎骨に対する手術であれば、レミフェンタニルを用いた全身麻酔に軽度の過換気を併用することで、組織酸素代謝を維持しつつ骨髄血流量を減少させることができるなど、レミフェンタニルの投与速度と換気条件を変化させることによって、良好な組織酸素代謝を維持しつつ組織血流量を減少させ、出血量の軽減に貢献するとともに、手術後に良好な創傷治癒をもたらす全身麻酔法を実施できる可能性が示唆された。