Prevention of catechin oligomer on sarcopenia via sympathethic nerve

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12731
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Shibaura Institute of Technology
• Principal Investigator: Osakabe Naomi 芝浦工業大学, システム理工学部, 教授 (30554852)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: カテキンオリゴマー / 交感神経 / サルコペニア / 筋委縮

Outline of Final Research Achievements

In the present study, we examined the effect of flavan 3-ols(FL) on disuse muscle atrophy induced by hindlimb suspension in mice. Male C57BL/6J mice were assigned to four groups as follows: unsuspended-vehicle, unsuspended- FL, suspended-vehicle, and suspended-FL. Mice in the vehicle treatment groups were administered distilled water and those in the FL treatment groups were dosed with FL (50mg/kg/day) for 2weeks. The weights of the gastrocnemius (GC), tibialis anterior (TA), and soleus (SOL), but not the extensor digitorum longus (EDL), decreased significantly in mice with hindlimb suspension (-11.8%, -16.5%, and -41.0%, respectively). This reduction in GC, TA, and SOL mass was inhibited by FL (-5.3%, +2.0%, and -16.6%, respectively). The FL increased the EDL weight >20% with or without hindlimb suspension. These results suggested that FL delayed disuse muscle atrophy by metabolic alteration.

Free Research Field

機能性食品学