in vitro reconstruction of HPA negative feedback system underlying neurodegenerative diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12870
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: The University of Tokyo
• Principal Investigator: Jimbo Yasuhiko 東京大学, 大学院工学系研究科(工学部), 教授 (20372401)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 脳神経疾患 / 細胞・組織 / シグナル伝達 / ナノバイオ

Outline of Final Research Achievements

To elucidate the mechanism by which the stress environment leads to neurodegenerative diseases, in vitro reconstruction of hypothalamus-pituitary-adrenal axis was studied. Cells including paraventricular nucleus of the hypothalamus, which is a starting point of GulcoCorticoid (GC) feedback, were successfully cultured. Hippocampal cells, which is one of the main targets of GC feedback, showed gradual changes in their spontaneous electrical activity patterns within one week under 10 μM GC administration.

Free Research Field

神経工学