2017 Fiscal Year Final Research Report
Development of a self-deploying and injectable drug release sheet
Project/Area Number |
16K12890
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Tohoku University |
Principal Investigator |
Kaji Hirokazu 東北大学, 工学研究科, 准教授 (70431525)
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Co-Investigator(Kenkyū-buntansha) |
阿部 俊明 東北大学, 医学系研究科, 教授 (90191858)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | 薬物送達システム |
Outline of Final Research Achievements |
A sheet-type device capable of self-deployment and sustained release of protein type drugs. The device consisted of a thin photopolymerized polyethylene glycol dimethacrylate (PEGDM) sheet and collagen microparticles (COLs), which were embedded in the sheet as drug carriers and for increased drug permeation. Since protein type drugs electrostatically interacted with the COLs, a prolonged sustained release was possible. The PEGDM/COLs device was flexible enough to be rolled up. When the device was immersed in water, the attractive forces acting between the sheet surfaces were relieved by water. Subsequently, the device unfolded by bending-stress relaxation. Moreover, the rolled-up device could be injected through a conventional syringe needle into water to recover its original shape. The developed sheet-type device provides the possibility of minimally invasive transplantation into diseased tissues, and could provide better therapeutic outcomes and reduce possible side effects.
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Free Research Field |
バイオ工学
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