Does lactate facilitate regeneration of injured skeletal muscle?

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K12942
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Toyohashi Sozo University
• Principal Investigator: OHNO Yoshitaka 豊橋創造大学, 保健医療学部, 講師 (80440808)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 骨格筋 / 細胞・組織

Outline of Final Research Achievements

The purpose of this study was to investigate the effects of lactate on the regeneration of injured skeletal muscle. Cardiotoxin (CTX) was injected into mouse tibialis anterior (TA) muscle. Oral administration of sodium lactate increased the muscle weight and number of Pax7-positive nuclei in CTX-injected TA muscle. Mouse myoblast C2C12 cells were differentiated to form myotubes. Lactate was administered to the differentiation medium. Lactate administration increased the diameter of C2C12 myotubes in a dose-dependent manner. Lactate administration also increased myonuclei number and upregulated the p42/44 extracellular signal-regulated kinase-1/2 (Erk1/2) signaling. These observations suggest that lactate may have a positive effect on the regeneration of injured skeletal muscle.

Free Research Field

リハビリテーション科学